IrisPublishers-Open access journals of Chemistry and Biochemistry

A Sensıtıve and Sımple Spectrofluorımetric Method for Analysıs Antı-Hypertensıve Drugs in Pharmaceutıcal Preparatıons

This work describes a simple, sensitive and reliable spectrofluorimetric method for the simultaneous determination of two anti-hypertensive drugs; benazepril. HCl (BEN) and hydrochlorothiazide (HCT) in their combined tablets. The method involved measurement of the native fluorescence at 389 nm (λEx 358 nm) and 389 nm (λEx 360 nm) for BEN and HCT respectively. Analytical performance of the proposed spectrofluorimetric procedure was statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, detection and quantification limits. Regression analysis showed good correlation between fluorescence intensity and concentration over the concentration ranges 1.0–5.0 and 1.25–6.25 μg mL-1 for BEN and HCT, respectively. No interference was observed from common pharmaceutical additives.

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